Simultaneous revascularization for critical coronary and peripheral vascular ischemia

Coronary revascularization for myocardial ischemia.

Bioresorbable Vascular Scaffolds for Coronary Revascularization.

Contemporary metallic drug-eluting stents are associated with very good 1-year outcomes but an ongoing risk of stent-related adverse events (thrombosis, myocardial infarction, restenosis) after 1 year. The pathogenesis of these very late events is likely related to the permanent presence of the metal stent frame or polymer. Bioresorbable scaffolds have been developed to provide drug delivery an...

Does Heart Affect Peripheral Vascular Resistance Following Myocardial Ischemia and Reperfusion?

Objective(s) The aim of this study was to investigate the overall effect of cardiac vasoactive factors during coronary occlusion and reperfusion on peripheral vascular tone, using a sequential isolated rabbit heart-ear perfusion model. Materials and Methods Isolated ears were perfused with the effluent of isolated hearts subjected to ischemia (30 min) and reperfusion (180 min, n=6). The comp...

Nanoscale strategies: treatment for peripheral vascular disease and critical limb ischemia.

Peripheral vascular disease (PVD) is one of the most prevalent vascular diseases in the U.S. afflicting an estimated 8 million people. Obstruction of peripheral arteries leads to insufficient nutrients and oxygen supply to extremities, which, if not treated properly, can potentially give rise to a severe condition called critical limb ischemia (CLI). CLI is associated with extremely high morbid...

Outcomes for clinical studies assessing drug and revascularization therapies for claudication and critical limb ischemia in peripheral artery disease.

P eripheral artery disease (PAD), which affects the large and medium arteries of the lower extremities, is a substantial cause of morbidity and health costs. Clinical studies assessing treatments for PAD guide clinical management but require standard definitions of disease and outcomes to ensure validity and consistency within and between studies. Prior guidelines for PAD outcomes in clinical t...